Tuesday, April 16, 2019

Book Signing

I will be signing copies of The Warship at Forbidden Planet London on Wednesday 1st May from 18.00 till 19.00. The link is here.


Their nemesis lies in wait . . .

Orlandine has destroyed the alien Jain super-soldier by deploying an actual black hole. And now that same weapon hoovers up clouds of lethal Jain technology, swarming within the deadly accretion disc’s event horizon. All seems just as she planned. Yet behind her back, forces incite rebellion on her home world, planning her assassination.

Neal Asher was born 1961 in Billericay, Essex, the son of a school teacher and a lecturer in applied mathematics who were also SF aficionados.

Prior to 2000 the Asher had stories accepted by British small press SF and fantasy magazines but post 2000 his writing career took flight. The majority of his novels are set within one future history, known as the Polity universe. The Polity encompasses many classic science fiction tropes including world-ruling artificial intelligences, androids, hive minds and aliens.



Wednesday, April 03, 2019

The Warship on Audible


I’m happy to say Peter Noble will be reading the audiobook of THE WARSHIP. But, as Peter is booked up, the audio will be released a little after the physical book - on 13th June. But stay tuned for earlier extracts as soon as it's recorded.




Friday, March 29, 2019

Senolytic Self-Experiments


I’ve written about this before but I think it worth going over again to clarify it in my own mind and for the interest of others.

Over the last few years I’ve read a lot about longevity and increasing healthspan. I’ll admit this is not for the usual reason I read science articles (grist for the writing mill) but for selfish reasons. Like anyone of my age (now 58) I am at the point where, for some years, I’ve noticed things are beginning to break down. Over five years ago I was a drinker and a smoker. In my thirties when I drank excessively and didn’t really suffer hangovers, but they came and steadily grew longer. At one time I smoked rollups without filters. Chest pains introduced filters, then nicotine gum in the mornings to delay the first cigarette, and an inhaler to open up my airways so I could sleep. Anxiety and depression kicked in after the death of my wife. This stopped the drinking because alcohol is a depressant with the aftereffect of anxiety, meanwhile a bigger focus on health along with the arrival of the electronic cigarette stopped me smoking. 

My health improved markedly from stopping these and from years of exercise to counter the anxiety. My anxiety waned and this steadily revealed that even with the improvement in my health, aging was having its effects, of course. Throughout this time, for the anxiety and looking for health improvements, I investigated and took all sorts of vitamins, herbal remedies and nootropics. This led into reading about longevity and healthspan, whereupon I discovered stuff about senescent cells and the substances that target them, senolytics.

A senescent cell is a kind of zombie cell. It goes wrong and instead of entering apoptosis (cell death) it goes into senescence, which means it won’t die but it also won’t replicate. The theory is that it does not sufficiently broadcast its damage for the body to destroy it; that the partial shutdown is a response to prevent it becoming cancerous. However, in that state it produces inflammatory chemicals that disrupt healthy cells around it. More and more of these accumulate as we get older and scientists are steadily revealing them as a root cause of many of the diseases of aging. If only we could take something to kill them off. . .

A gobsmacking study on mice appeared. It had been discovered (somehow) that a combination of the cancer drug Dasatinib and the supplement quercetin were a senolytic. When given to aged mice their health improved markedly throughout their bodies and it extended their lifespan by 36%. Many people began experimenting with this combo and I too considered it. Unfortunately trying to get hold of Dasatinib is a risky business since it is prescription only. There are many places that sell it, especially in China, but will you actually be getting the real deal? I’ve also yet to see much on any positive effects from the self-experimenters. I put the idea aside, since I’m not dead yet, and continued reading.

After the success of the above combo (in mice) researchers began looking for other senolytics and testing them. Two were highlighted: fisetin, a flavonoid like quercetin but found in strawberries and piperlongumine a constituent of the long pepper. Fisetin it turned out was better than Dasatinib and quercetin, it also has no known ill effects when taken by humans and is a supplement you can buy. I read the mouse study and made the calculations – there is a formula to convert from a mouse to a human based on skin area. It turned out, that to do the equivalent of the mouse study in me, I would need to take (roughly) 640mg of fisetin per day, with some form of oil since it is lipophilic, for five days. I upped this to 1000mgs for maximum effect.

At this time I had also had further health improvements through fasting two days a week and dropping a lot of fat, getting some better sleep through using melatonin, and was still taking a variety of supplements on top of that. I also became a regular gym goer. So one must judge anything I write about this with caution. In no way have I conducted a carefully-moderated clinical trial. At the time I also found it difficult to recover from my work in the gym. I felt very tired all the time. I dressed up my response to this as ‘power napping’ but really it was an old bugger needing to take a snooze. I took a couple of courses of fisetin as detailed, over a few weeks, and felt particularly rough each time – like I was developing a cold – a had anxiety (maybe a nocebo effect since I aimed to kill certain cells in my body). Afterwards I just ate well when not fasting. Had it done anything? I thought not, and I thought that even if it had I might not notice effects. However, some weeks after this I noticed I no longer needed my power naps. This could have been an effect of fasting, or the melatonin or something else I was taking. It could all be placebo. But I found it encouraging enough not to dismiss it, and maybe try it again.

What percentage of my senescent cells did it destroy, if any at all? How quickly do senescent cells build up in the body? These are questions I simply cannot answer. I decided to try again on the basis that I probably still had plenty of senescent cells in me and the side-effects aren’t too nasty. Last Sunday night I took my first dose. On Monday I took another while fasting through till Tuesday (beginning with a dry fast of 16 hours) – 40 hours in total. I took doses through until Thursday. I felt particularly rough. I had symptoms of a developing cold again, a cold sore attempting to break out, feelings of extreme cold even when eating (so not an effect of fasting), a crappy mood and a lot of anxiety. I needed to have a sleep during the last day and that lasted two hours, followed by eight hours that night. I am now into my first day without a dose and am recovering quickly. 

Again I must make the point that this is in no way scientific. However, I simply cannot put the nasty effects down to anything other than the fisetin. This is also confirmed by someone else who has done the same as me. Perhaps such large doses just fuck me up big time and kill no senescent cells at all. But worth a punt. I will see in the ensuing days and weeks if any positive effects are noticeable. Meanwhile I look to the increasing number of biotech companies developing their own senolytics and putting them through trials. 

Interesting times.  


Monday, March 25, 2019

A Couple of Short Stories Published.


Again about stories I recently wrote when I had time to spare from work on my books. A few of them have been taken now and two are now available. The first is Monitor Logan – basically a far future High Plains Drifter and this can be found in the World War Four anthologyfrom Zombie Pirate Publishing.  



The second is Berserker Captain a story of sword-wielding violence appropriate for Ian Whates’ Legends Three from Newcon Press in homage of David Gemmell.



More to come. . .

Visiting Galleries

Some may have noticed, if they follow me on Facebook or Twitter, that I’ve been wandering into a few art galleries and museums lately. The blame for this can be laid squarely at the door of one Julie Ann McCartney, and she’s also to blame for a change in my usual morning reading of ten science articles. They now make way for two or three articles on art and history. I know that some are a little concerned about this change: Oh hell, is he getting all cultural and artsy? Is he going soft on us? Never fear.


Right from when I was writing my first short autobiographies or answering interview questions, I told of how I chose to be a writer. When I was a kid I had interests in all sorts of things. These included biology, painting and drawing, electronics, sculpture, chemistry, writing of course and other things besides. However, in my early 20s (if not before) I decided I had to concentrate on just one of these if I was ever to achieve anything. If I did not I would be a Jack of all trades but master of none. I chose writing because in that I could incorporate all those other subjects. In the respect of my science and technology interest this was especially the case when it came to SF.

But all is grist to the writing mill in the end. I should also add that the mill needs feeding and often with something new. If you don’t feed it yes, sure, you can still produce but ideas might be lacking. And if you feed it the same old stuff all the time what comes out may well get stale. Please excuse the extended and increasingly contorted metaphor. But what I’m getting round to here is that new experiences, ideas and perspectives can be invigorating for a writer, and they have been.

As I said in previous posts I recently turned from writing novels to writing short stories (though am now back editing the latest novel). I started out with a fairly traditional alien contact story, got into some Polity biotech stuff that produced one story and germinated an idea for a novella. I then wrote another novella that concerned my recent reading on longevity and the new biotech start-ups we are seeing. Next I started writing a story about a woman with moveable tattoos that transformed into something strange about her skin having an implanted AI, and in this I found myself in the Polity art world.

Now I was really using those gallery and museum visits. That story completed I then had a seriously weird dream about a biotech future, sat to write that down before my morning visit to the gym while still in a bit of a dream state, and glanced at a book Julie bought for me for my birthday on the artist Hieronymus Bosch. It fit at once. This start has now turned into another weird one: far future biotech and the monsters of Bosch born to exact vengeance for a crime. I’ve completed that at 20,000 words and will finish editing it later.

Glad I visited those galleries.

Thursday, February 14, 2019

Writing Update


As is usual I haven’t been blogging very much so time to catch up. Early last year I finished the first draft of the third book of the Rise of the Jain trilogy – provisionally titled The Human. Thereafter I thought it time to get down to writing some short stories. I used an extracted plot thread of 20,000 words with the intention of turning it into something short. It actually turned into a novel called Jack Four I completed to first draft on the 21st November. I then really did get down to working on some short stories – as with the books between spells of editing and writing other bits and pieces.



It’s been fun rediscovering my enjoyment of the tight writing and invention of short stories. In December I wrote a completely non-Polity near future story called An Alien on Crete. Shortly after that, in the same month I completed The Host – a Polity story involving weird alien biology and a forensic AI. I felt an idea in The Host could be expanded and did so, completing Moral Biology (a novella) in early January. My science reading has included a great deal about longevity, and I completed another novella called Longevity Averaging near the end of the month, then at the end of the month another Polity story called Skin, set in far future London and involving, well, skin. I’m now venturing off into something deeply biotech and weird, with links to the monsters of Hieronymus Bosch and guess I’ll have that done in a week or so. 

But this interlude, enjoyable as it has been, must come to an end when I return to editing The Human ready to be handed in to Macmillan in a few months. One thing I rediscovered while writing these stories was just how good it is to print then damned things out to check them. I’ll do the same with the book going through it a chapter at a time with a pen. I also have in mind a small epilogue I need to add, so there’s that.

In all it has been a productive time and I’m happy to have returned to form. Ciao for now.  

Friday, January 04, 2019

Man in High Castle on Amazon

Another series I found on Amazon TV, which I have only just finished watching, is Man in High Castle. Based on the Philip K Dick book of the same name it gives us a parallel world in which the Nazis and the Japanese won the war.


This is grim and bleak but the acting is good and the characters engage. Films are turning up in this parallel, from that Man in High Castle, of events in our own world and are disseminated by rebels, though it is never clear what effect they could possibly have. Maybe the knowledge that things could be different is enough? Mainly this covers the day to day lives of the people in that world – what it is like to live under such a regime – though the bones of story begin to appear with travellers from other worlds, the growing rebellion and the Nazi’s awareness of these and their response. However I wonder if it has the legs to go much beyond the three seasons shown. Mostly it is reliant on its world-building, of the shiver one feels seeing those black uniforms in places like New York, of swastika flags hanging on familiar buildings, and Japanese soldiers beheading citizens – the brutality of it all running on for decades beyond the war – and the frisson one feels seeing monsters like Himmler, Mengele and Hitler himself living on into the 60s. It relies in the end on it being a well-imagined parallel world, and that is not enough. I hope it does keep on its feet since it is very good, but I suspect is will die in the long whimper of extended franchise. 

Thursday, December 27, 2018

Children of Time - Adrian Tchaikovsky

I picked up an Adrian Tchaikovsky book before (Empire in Black and Gold), recollect enjoying what I read of it, but it unfortunately fell during a time when some shitty things were happening in my life and I lost my reading mojo. Now I’ve read Children of Time and am considering going back to take a look at those Shadows of the Apt books.


If any book appears here it is because I finished it, so right away it is to me an enjoyable book. Life is too short for anything else and anything that doesn’t make the grade after a few chapters ends up in the charity shop bag. In fact that usually happens after just a few pages. This one made the grade in spades.

Two story threads weave the whole together with on the one hand the travails of the survivors of the human race travelling out in an arc ship to find the remains of a previous old empire, and on the other an uplift project (the space station concerned of course being called the Brin) – the terraforming of a world and the placement of a ‘barrel of monkeys’ there to rise to civilization. The driver of this is a nano-virus that accelerates evolution by dint of making acquired abilities heritable. This is overseen by Doctor Avrana Kern who, to survive during a rebellion in that old empire, becomes an amalgam of an upload of herself, her cold coffin body and the computer system of the satellite she occupies. The project goes wrong, and what rises to intelligence and civilization is somewhat unexpected. Okay, that’s enough, since I don’t want to give the plot away.

This being a doorstep of a book I had my doubts about whether I could stick with it, but over 600 pages of science fiction goodness I enjoyed myself immensely. The rise of the ‘alien’ race parallels (and nicely diverges from) the rise of humanity and the world-building there is excellent. I did get an ‘oh shit’ moment with the battle of the sexes turned on its head (but for perfectly understandable biological reasons) but fortunately it didn’t lapse into proselytizing on gender politics as seems par for the course elsewhere. The thread aboard the arc ship kept my nose in the book too – at no point did I think ‘Nah, move along’. I cared about the characters there and on the terraformed world.

Thoroughly recommended.   

Sunday, December 23, 2018

Revenger - Alastair Reynolds (A Christmas Story)


This was written a couple of years ago, but it seems appropriate to post this now, since it has baubles in it. 

I recently bought a stack of old SF books from a second-hand shop. Unfortunately it seems my discernment has changed over the years and quite a few of them went into a bag after a few pages to go back to a charity shop. I also went into Waterstones and bought some new books from writers who have never really failed me, and one of those is Alastair Reynolds. Finally giving up on the second-hand stuff I picked up Revenger.


Here we have a far future human civilization after the planets have been broken up and formed into millions of small worlds called the Congregation. There have been many ‘occupations’ of these worlds – the rises and falls of previous civilizations – which have left all sorts of high tech goodies scattered across space. These are often to be found in ‘baubles’ – worlds often concealed under force fields that open intermittently. This opening can be predicted by augury, usually by experts aboard the sailing ships that seek out this treasure. Of course the sailing ships run the perfectly feasible technology of light sails but, you know, there are pirates too.

Arthur C Clarke tells us that ‘Any sufficiently advanced technology is indistinguishable from magic’. Reynolds takes hold of this and gives us alchemy, a form of phrenology that delighted me, and all the dusty weirdness where advanced technology has become ancient, whipped up with a riff from Pirates of the Caribbean. I had a ball with this.

Recommended.  


Thursday, December 13, 2018

Bosch and Chicago PD on Amazon


Beginning to scrabble about to find something to watch on Amazon I had a punt at some of the cop shows available.


The first of these was Bosch, Hieronymus or Harry Bosch. The use of this name and the style of the whole thing leads me to suspect these are based on books. The plotting was tight, I cared about the characters and, frankly, I enjoyed four seasons of this and will probably enjoy more as they appear. The main character plays his role well – I’ve seen him elsewhere too (Agents of Shield). The only problem I have with him is that he is supposed to be a tough ex Special Forces guy, but physically is not at all convincing.



Hoping to find something more in the same vein I next tried Chicago PD. This started out well with a tough cop who had a beat them till they confess technique for solving crimes. The characters and story lines all gelled and his ‘intelligence’ unit had to deal with some nasty crimes using morally grey methods. I enjoyed the subplots with the uniformed officers too and to a certain extent this reminded me of The Shield. However, after a couple of seasons it began to wander off course. Too much lengthy emoting seemed to become the thing – long stretches of cops suffering emotional problems and being hugely empathetic. And, increasingly, the modern disease of TV and film began to encroach. I’m up to Season Four and finding myself fast-forwarding. There doesn’t seem to be an episode now without politically correct proselytizing shoehorned in and, as is the case when this bullshit starts, the plots are falling apart and the characters ceasing to be believable. Shame really.  

Sunday, December 09, 2018

Another look at Ecigs

Recently I put up a so-called science article on vaping in which the writers repeated the popcorn lung myth and even went so far as to say, "There is still no definitive answer on whether these risks (of vaping) outweigh the benefits of switching from traditional tobacco cigarettes". This is despite even the BMA, who were anti ecigs in the beginning, rating them as 99% less harmful than tobacco cigarettes. 


Numerous comments ensued, some by those whose lives, and health, have been vastly improved by switching from smoking to vaping, some by those who are against it. I found myself getting irritated by the latter, and somewhat defensive. This of course is not unusual in someone who has used vaping to quit cigarettes. I smoked for about forty years. I took my first puff on a cigarette before I reached my teens and was a full-time smoker by the age of sixteen. I grew up in a society in which smoking was common and allowed just about everywhere. I had heard of course that smoking is bad for you but, as with many, the reality of this did not impinge on me until I felt intimations of mortality in later life. From my 20s to 30s I smoked unfiltered roll-ups but started noticing chest pains, in my 30s to 40s I was using filters but the pains returned. In my late 40s I was delaying the first cigarette of the day with nicotine gum. Throughout all this time I made numerous attempts to quit, on a couple of occasions giving up for as much as a year. I tried NRT and it wasn’t much help. This bears out the statistics on NRT with its dismal quit rate and massive cost to the NHS for each smoker who does quit using by it. By my 50s I had crappy facial skin, frequent eye infections, often used an inhaler to be able to sleep at night and at other times too. 

Six or seven years ago Caroline and I had come to the conclusion we had to quit soon – smoking was fucking us up. Out on Crete we saw it in the people around us, with just about every smoker in their 60s facing serious health problems: heart stents and bypasses, emphysema, asthma and of course cancer. Out there Caroline became ill and this gave us a final push and, before heading back to the UK, friends gave us a box of quit smoking items. The usual NRT stuff was in there, but also some early vaporizers. These, when they actually worked, worked very well. Back in the UK I investigated further and discovered a vaping subculture and through that the next generations of vaporizers. Using these more advanced devices we both quit with surprising ease. In my case, within just a few weeks, I no longer needed the inhalers and the pain left my chest. Over further time my skin cleared up and the eye infections all but went away. As I have detailed here before, Caroline died of bowel cancer. Whether that was due to smoking can never be ascertained, but I would say it certainly didn’t help.

On my return to Crete I discovered other changes. My first time swimming again, rather than have to stop after a few hundred yards to catch my breath and cough the debris from my lungs, I swam a straight mile with ease. Also any form of exercise was easier and I did a lot. As a smoker it had almost felt like a pointless pursuit. Vaping had been practically miraculous for me and, in the ensuing years around the world, smoking rates plummeted because of it. But there was a big nasty worm in this apple.

I was utterly baffled by the rise in anti-vaping propaganda. Here was something – a product of small industry – improving and saving people’s lives. I read much of this nonsense: a Daily Mail article screaming about the carcinogens in ecig vapour, it later turning out that the quantity was minimal – no more than in NRT nicotine patches – and below the threshold were any effect could be detected; the panic about diacetyl in ecigs producing popcorn lung, despite the fact that there is more of the stuff in cigarettes and not much in the way of popcorn lung in smokers; ecigs as a ‘gateway’ into smoking for ‘the children’ when all research showed that they did the opposite. Article after article appeared whose sum aim seemed to be to stamp down on, control and even stop an activity that was saving lives. It even became legislation in the EU with the damned Tobacco Products Directive reducing the size of ecig tanks and the strength of their liquids so that they were a lot less effective than they had been. I even began hearing the madness that vaping was worse than smoking. Where was all this coming from? 

Crazily a lot of it came from people in the ‘health lobby’. It was almost as if, having spent years singing the ‘quit or die’ mantra and pushing to make cigarettes illegal, they were jealous of something that had turned up from outfield to do a better job than them. Further one can suppose that they were protecting their jobs and inflated salaries. Not so crazily Big Tobacco and drugs companies were against it. The Tobacco Products directive was partially the result of their lobbying of the corporatist (crony capitalist) EU. In both cases this was about sales, in the first sales of cigarettes and in the second the shitloads of money the drugs companies were making from NRT and, if you want to be really cynical, from the medication of smoking related diseases. Governments themselves are also culpable. Ecigs are a disruptive technology and governments are resistant to change, especially when it comes to sources of revenue.

But though the above explains some of the reasons for much of the propaganda it does not fully elucidate it. The ‘fake news’ and such pushes for legislation, control and bans, cannot operate in a vacuum because they need lots of people inclined to believe the first and on board with the rest. Why are many people without financial motives against ecigs? Having had many discussions about this I’ve come to some conclusions.

First off the public has been subject to decades of social engineering – indoctrination – against smoking. Some don’t quite understand how deeply rooted in their minds this is while, admittedly, others have always disliked smoking. A portion of both are against ecigs because they cannot see them as different from smoking. A person is breathing in ‘addictive’ nicotine and producing a visible cloud. How is this different from smoking? The simple reality here is that, on the whole, only those who have smoked and quit by using ecigs fully understand the differences. Over years of social engineering people have also been told nicotine is an evil addictive substance. This is a fallacy. Nicotine is only ‘evil’ by association with smoking. By itself it causes little more damage than the addictive substance caffeine. It is the delivery system – the cigarette – that causes the damage with its carcinogens, tar, monoxide, burning leaves and heavy metals. Ecigs don’t do that. ‘But you’re addicted!’ we hear the cry, because obviously this is a bad thing. Is it? Why is addiction, per se, a bad thing? 

Again this is association. Addiction has, historically, always resulted in damage – to health, to finances, to the mind, whatever. Whenever people hear the word they immediately think of smokers, or someone shoving heroin into their arm, people stoned out of their skulls in rotting tenements, people skull-fucked on cannabis and all the outfall of these. However, if addiction results in none of the above, why is it bad? Quite simply it isn’t. The attitude to addiction is a mind-set, programming, irrational. 

Beyond addiction we come to the vapour an ecig produces. Part of the indoctrination against smoking has been the risible ‘studies’ about the damaging effects of second-hand smoke. These studies have even slid into the Twilight Zone of third-hand smoke. Many people (not all) have been taught to fear it and be disgusted by it, even more than the car fumes that are doing them more damage. To a certain extent I agree with these reactions, but my agreement is limited. Anyone suffering from a lung complaint has reason to abhor cigarette smoke. And they of course have every right to complain. As for the disgust . . . it is only when you stop smoking do you realize how strong it smells and how much it lingers. Is it a bad smell, though? To some people it always has been, but to the majority it has only become such after being subjected to the aforesaid indoctrination. Very few people thought tobacco smoke was horrible fifty years ago, many in fact liked the whiff of a cigar or a pipe.

Now, when some see ecig vapour, which is little more than flavoured steam with a nicotine quantity that has practically zero effect on them, they react as they have been indoctrinated to react to cigarette smoke. Laughably many of these same people will be going home to put a new cartridge in their plug-in air freshener that does much the same thing as an ecig. Ecig vapour dissipates fast and the biggest ill effect most people will get from it is being subjected to a whiff of caramel or banana. Yet, they will wave their hands and cough dramatically to try and exclude the horrible social pariah who, despite all the evidence, they still think of as a smoker.                  

But here comes the ‘however’. Though many are reacting as they have been indoctrinated to react to cigarette smoke, there are others whose reaction may be perfectly valid. When I’ve been involved in discussions about this I’ve heard mentioned, with some ire, big clouds of vapour. My own ecig produces a brief waft of vapour that disappears in a few seconds and in some situations I will ‘stealth vape’ i.e. hold the vapour in long enough for it to settle so I breath out nothing visible. But, unfortunately, there are vapers for whom the objective of the practice is not to quell addiction, enjoy a hit of nicotine or the flavour of the liquid they are using, but to produce as large a cloud of vapour as they can manage. When I first saw this, in light of ecig advocates fighting to prevent bans and killing legislation, I felt it was madness. Such a cloud can affect the breathing of others, especially if they have some sensitivity or ailment like asthma, and it can piss off those with none of these. 

Here I have to add here that because of the aforesaid indoctrination many are already predisposed to be pissed off, and to have hysterical reactions which could be the root of ill effects. It’s not just the indoctrinated, but quite often ex-smokers. Part of the requirement of many of the latter, in giving up, was learning to hate their habit, and anything remotely like it.

Why do some vapers produce these big clouds? I think it partially relates to the hand waving and dramatic coughing reactions I mentioned above. People can be pushed but only so far, then they push back. The big cloud vapers are probably saying, ‘I can do this here, it’s legal, stop your dramatics and just fuck off.’ There’s a sense of rebellion in it. They were smokers who were turned into pariahs, found a way to stop smoking, only to then discover that some people still classify them as social pariahs, and they’re holding up a middle finger. It’s not clever and it’s not helping along this health revolution, but as we know, whenever a good thing comes along there are always those inclined to screw it up. 

Friday, November 02, 2018

Book Sale Last Page

See the first page in this series for contact and postage details.


Book Sale Page Six

See the first post in this series for contact and postage details.


Book Sale Page Five

Contact details and stuff about postage and packing is in the first post about these books, so check back. Obviously some of the books in the previous posts will be gone.



Wednesday, October 31, 2018

Book Sale Page Four


As before, contact details and stuff about postage etc are on the first of these posts.


Fasting and Fisetin

As far as I understand it fasting has a multitude of benefits beyond just losing weight. You have autophagy and apoptosis, an increase in growth hormone, a reduction in insulin resistance, a reduction through the loss of fat in production of oestrogen and much else besides on the cellular level. You’re also reducing or getting rid of that damaging visceral fat. In fact, many new drugs being developed for dealing with what has been dubbed ‘metabolic syndrome’, i.e. poor lifestyle choices, have effects that are the same as those fasting produces. Psychologically you’re taking control of your body and that, though I hate the word, is empowering.

Combine fasting with exercise and the benefits ramp up. I’ve been fasting now for nigh on two months spending two days a week without food. Also, throughout this time, I’ve been walking longish distances at the weekends and hitting the gym for 50mins three to four times every week. I’m steadily closing on having lost 20lbs of fat, feel light and have better muscle definition, and am feeling pretty good about that. But, as ever, I have to go one step further.

My weight loss has been steadily declining. At the start of this fasting period I was losing (if you discount the large water loss) getting on for 3lbs a week. It’s now down to about half that. I know from my reading that the longer you fast the longer you spend in ketosis and autophagy so the greater benefits you get from them. Because Julie was going away this last weekend I decided to go for a four-day fast and see how I got on with that.

Other reading added something else too. I know that to retard the effects of aging and for good health, weight loss (best through fasting) and exercise are two of the things we as individuals can do. But now another looms on the horizon. A lot, if not most, of the damage of aging comes from senescent cells. These are cells that have malfunctioned but, due to the nature of that malfunction, have not been destroyed by the body. They sit inside us producing SASP – Senescent-Associated Secretory Phenotype – which causes inflammation and has been linked to many disorders. Now studies have shown that by using a senolytic – a drug that causes apoptosis (death) of these malfunctioning cells – one can to a degree reverse some of the effects of aging.

Few senolytics are available. The most effective (in mouse studies) has been a combination of a cancer drug called dasatinib and an over-the-counter supplement called quercetin. The quercetin doesn’t do very much by itself. But there are others that are easily available to us. One is in long pepper – a substance called piperlongumin. Another is fisetin – the flavonoid that gives strawberries their colour. Apparently this last may be best of all and can work without a toxic cancer drug involved. So I decided to use some.

Apparently just a few fisetin capsules don’t have the required senolytic effect. You need to megadose with it, but this stuff supposedly has nothing in the way of adverse side effects. My searches and calculations gave me a dosage of 640mg of pure fisetin (the capsules you buy will have a percentage of fisetin) per day for five days. It is also lipophilic so taking it with an oil of some kind will promote absorption. I raised the dosage to 1000mg a day since I was doing it for four days and not five. The first two days I emptied the capsules into MCT oil and drank it. The stuff tasted foul and after the first two days I could not face it like that so took it in capsule form with fish oil and an MCT/coconut oil coffee on top. That was better.

Now, on the day following all of this, I don’t yet know what effects it has had beyond the immediate effects of the fast itself. The fisetin might not have been sufficiently bioavailable taken by mouth. It might also be the case, as with exercise, that the best results only show up properly after rest and food. Of course I may see nothing at all. Killing off senescent cells does not turn one into superman, but returns one to a previous normal – while the effects of aging are very gradual indeed. 

Tuesday, October 30, 2018

Book Sale Page Three

Okay, please read this post before contacting me.

The new copies of Polity Agent and Line War below have gone. One and three on the list below.

Details on contact, postage etc are on my first post about these. Scroll down. Also be aware that some of the books in the previous posts have gone. Sorry to disappoint.

I'll also add here, just on the off-chance, that I have a load of paperbacks of these in German if anyone is interested. Perhaps some Germans read this, or language students, or someone with other connections to that country?


Monday, October 29, 2018

Book Sale Page Two

Contact details and information regarding postage and packing are on the previous post. Unfortunately the uncorrected proof copy of Polity Agent at the bottom here is now gone. I left that on there just so you will know that if you want something, then order it quickly. As on the previous post: first come first served.

Sunday, October 28, 2018

Book Sale!

Page One

Mainly so I can keep track I'm going to put these up over a few days. To the prices here I will have to add postage and packing. Dependent on where you are this can amount to as much as if not more than the price of the book. The last time I did this books went missing in the post, so these will have to be either signed for or tracked or both (I haven't sorted that out yet). If you follow me on Facebook or Twitter you can contact me there, otherwise neallewisasheratgmaildotcom. First come first served. Please don't ask me about books that do not or have not yet appeared in these posts.

I will sign the books and write in some message as preferred. You'll also get one of my home made (signed) bookmarks with each purchase.


Tuesday, October 23, 2018

Hannibal - Netflix Series

I enjoyed this to begin with as it covered the ground of Red Dragon and expanded on it. The lurid murders, convoluted plots and the psychological interplay between the characters satisfied something in my twisted psyche. The camera work was also excellent with some equally satisfying dream sequences. It was of course utterly fantastical but I did not find it an effort to suspend disbelief. But at the back of my mind resided the sure knowledge that the franchise would be extended and the series would probably die, as many do, by stretching an increasingly meagre plot over many episodes. Then along came series two starting out with a sequence from some months in the future that raised my hopes that this would continue to adhere (loosely) to Red Dragon and that it did have a beginning, middle and then end.


The second season started out well with this, but then came an expansion of the psychobabble, the dream sequences and the ‘artistic’ camera work. These last two kinda reminded me of the new Blade Runner film where art forgot story and went wandering off by itself. It even had the same ramping up of the music volume in an attempt to impart meaning where there was none. But I stuck with it because of that initial sequence. In season three it slid into the plot of the film (and book) Hannibal but with its own particular twist on those. Maybe it would have been okay if someone had reined in the ‘artistic filming’ but I suspect someone told them it was really good so they did more of it. The psychobabble also increased to fill the growing void and segued into the nonsensical. The plot was being stretched thin and hardly covered the holes. A few episodes in I finally gave up. Other viewers also gave up because this was not renewed after the third season.

This is, unfortunately, common in many series I see on Netflix. Franchise extending kills them. Film makers should have the courage to propose series that end rather continue sucking at that teat. At best, if they don’t, what starts out as promising turns into soap opera. The money men and executives behind them should also learn from this growing catalogue of failure. I don’t hold out much hope.